Protein A Protein

Produktnummer ABIN2648105

Produktdetails

Target: Protein A

Protein-Typ: Native

Spezies: Staphylococcus aureus

Quelle: Staphylococcus aureus

Produktmerkmale: Immunoglobulin-binding bacterial Protein A solution
Protein Source: Staphylococcus aureus

Reinheit: > 95 % pure

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C.

Antigendetails

Target: Protein A

Abstract: Protein A Produkte

Hintergrund: Protein A is a 40-60 kDa MSCRAMM surface protein originally found in the cell wall of the bacteria Staphylococcus aureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two-component system called ArlS-ArlR. It has found use in biochemical research because of its ability to bind immunoglobulins. It binds proteins from many of mammalian species, most notably IgGs. It binds with the Fc region of immunoglobulins through interaction with the heavy chain. The result of this type of interaction is that, in serum, the bacteria will bind IgG molecules in the wrong orientation (in relation to normal antibody function) on their surface which disrupts opsonization and phagocytosis.
Description: Staphylococcus aureus.