CXCL17 Protein (AA 24-119)

Produktnummer ABIN2666918

Produktdetails

Target: CXCL17 (Chemokine (C-X-C Motif) Ligand 17 (CXCL17))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 24-119

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Flow Cytometry (FACS)

Reinheit: > 98 % , as determined by Coomassie stained SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau:

Less than 0.01 ng per μg cytokine as determined by the LAL method.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Biological activity: Bioactivity was measured by its antimicrobial activity (E.coli) in a dose dependent manner.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.

Buffer: 0.22 μm filtered protein solution is in PBS.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.

Antigendetails

Target: CXCL17 (Chemokine (C-X-C Motif) Ligand 17 (CXCL17))

Andere Bezeichnung: CXCL17 (CXCL17 Produkte)

Synonyme: DMC Protein, Dcip1 Protein, UNQ473 Protein, VCC-1 Protein, VCC1 Protein, Vcc1 Protein, RGD1304717 Protein, C-X-C motif chemokine ligand 17 Protein, chemokine (C-X-C motif) ligand 17 Protein, CXCL17 Protein, Cxcl17 Protein

Hintergrund: CXCL17 is the latest identified member of the CXC chemokine family and may contribute to tumor angiogenesis and progression. Ectopic expression of human CXCL17 in HUVEC significantly upregulated the RNA level of genes involved in angiogenesis including VEGF-A and basic FGF. NIH3T3 cells overexpressing human or mouse CXCL17 developed rapid growing tumors in mice. In vitro chemotaxis assay shows that human CXCL17 can induce migration of CD14+ monocytes and CD11c+ immature dendritic cells from human peripheral blood, and mouse CXCL17 can induce CD11b+Gr1highF4/80- cells from mouse spleen cells. CXCL17 also shows broad antimicrobial activity by disrupting bacterial membrane. High levels of CXCL17 have been detected in bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis.

Molekulargewicht: The 96 amino acid recombinant protein has a predicted molecular mass of approximately 11.3 kDa. The DTT-reduced protein migrates at approximately 11.3 kDa and non-reduced protein migrates at approximately 24 kDa by SDS-PAGE. The N-terminal amino acid is L