Lamin A/C Protein (LMNA)

Produktnummer ABIN2669331

Produktdetails

Target: Lamin A/C (LMNA)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB), SDS-PAGE (SDS)

Produktmerkmale: Recombinant human lamin A is a 645 amino acids protein with a molecular weight of 70 kDa.

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 20 mM phosphate buffer pH 7.0, 0.5M NaCl, 1 mM DTT, 1.5 mM EDTA, 20 % (v/v) glycerol

Lagerung: -20 °C

Antigendetails

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin A (LMNA Produkte)

Hintergrund: Lamin A is a major component of the nuclear lamina, a dynamic meshwork located just under the nuclear envelope and it is encoded by lamin A/C gene (LMNA). Lamin A is synthesized as a longer precursor, prelamin A (code REP0038), that in vivo undergoes to serial post-translational modifications that lead to mature lamin A. Different mutations in the LMNA gene have been associated with different diseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familiar partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus