Ataxin 1 Protein (ATXN1) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target Alle Ataxin 1 (ATXN1) Proteine anzeigen
- Ataxin 1 (ATXN1)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 1
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Ataxin 1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human Ataxin-1 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product ATXN1 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- Ataxin 1 (ATXN1)
- Andere Bezeichnung
- Ataxin-1 (ATXN1 Produkte)
- Synonyme
- ATX1 Protein, D6S504E Protein, SCA1 Protein, ATXN1 Protein, ataxin 1b Protein, atxn1 Protein, 2900016G23Rik Protein, Atx1 Protein, C85907 Protein, ENSMUSG00000074917 Protein, Gm10786 Protein, Sca1 Protein, CG4547 Protein, Dmel\\CG4547 Protein, dAtx-1 Protein, dAtx1 Protein, sca1 Protein, ataxin 1 Protein, ataxin 1b Protein, Ataxin 1 Protein, ATXN1 Protein, atxn1b Protein, Atxn1 Protein, Atx-1 Protein
- Hintergrund
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.
- Molekulargewicht
- 86.7 kDa
- NCBI Accession
- NP_000323
- Pathways
- Synaptic Membrane
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