C11orf73 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target Alle C11orf73 Proteine anzeigen
- C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 1
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses C11orf73 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human C11orf73 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product C11orf73 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- C11orf73 (Chromosome 11 Open Reading Frame 73 (C11orf73))
- Andere Bezeichnung
- c11orf73 (C11orf73 Produkte)
- Synonyme
- C11orf73 Protein, HSPC179 Protein, Hikeshi Protein, L7RN6 Protein, OPI10 Protein, Hikeshi, heat shock protein nuclear import factor Protein, Hikeshi, heat shock protein nuclear import factor L homeolog Protein, HIKESHI Protein, hikeshi.L Protein, hikeshi Protein, Hikeshi Protein
- Hintergrund
- This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress.
- Molekulargewicht
- 21.4 kDa
- NCBI Accession
- NP_057485
- Pathways
- Protein targeting to Nucleus
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