GFRA2 Protein (Transcript Variant 2)

Produktnummer ABIN2721854

Produktdetails

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human GFRA2 / GDNFR-beta (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin-Niveau: < 0.1 EU per μg protein as determined by LAL test

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Lyophilized from a 0.2 μM filtered solution of 20 mM Phosphate buffer, 150 mM NaCl, pH 7.2. Stable for at least 6 months from date of receipt under proper storage and handling conditions.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: GFRA2 (GDNF Family Receptor alpha 2 (GFRA2))

Andere Bezeichnung: Gfra2,gdnfr-beta (GFRA2 Produkte)

Synonyme: GDNFRB Protein, NRTNR-ALPHA Protein, NTNRA Protein, RETL2 Protein, TRNR2 Protein, Retl2 Protein, NTNRALPHA Protein, ntnra Protein, retl2 Protein, trnr2 Protein, gdnfrb Protein, nrtnr-alpha Protein, gfra2 Protein, GDNF family receptor alpha 2 Protein, glial cell line derived neurotrophic factor family receptor alpha 2 Protein, GDNF family receptor alpha 2a Protein, GFRA2 Protein, Gfra2 Protein, gfra2 Protein, gfra2a Protein

Hintergrund: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 47.8 kDa

NCBI Accession: NP_001158510