HERPUD1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2722638

Produktdetails

Target: HERPUD1 (Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1 (HERPUD1))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses HERPUD1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human HERPUD1 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: HERPUD1 (Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 1 (HERPUD1))

Andere Bezeichnung: Herpud1 (HERPUD1 Produkte)

Synonyme: herpud1-a Protein, herp Protein, herpud1 Protein, mif1 Protein, sup Protein, HERPUD1 Protein, zgc:114134 Protein, HERP Protein, Mif1 Protein, SUP Protein, Herp Protein, Mifl Protein, Sup Protein, homocysteine inducible ER protein with ubiquitin like domain 1 S homeolog Protein, homocysteine inducible ER protein with ubiquitin like domain 1 L homeolog Protein, homocysteine inducible ER protein with ubiquitin like domain 1 Protein, homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Protein, herpud1.S Protein, herpud1.L Protein, herpud1 Protein, HERPUD1 Protein, Herpud1 Protein

Hintergrund: The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined.

Molekulargewicht: 43.4 kDa

NCBI Accession: NP_001010989

Pathways: ER-Nucleus Signaling