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MKNK2 Protein (His tag)

MKNK2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Produktnummer ABIN2726085
  • Target Alle MKNK2 Proteine anzeigen
    MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
    Protein-Typ
    Recombinant
    Spezies
    • 5
    • 1
    • 1
    • 1
    Human
    Quelle
    • 2
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses MKNK2 Protein ist gelabelt mit His tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human MKNK2 (full length, N-term HIS tag, transcript variant 1) protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product MKNK2 Protein
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the N-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
    Andere Bezeichnung
    Mknk2 (MKNK2 Produkte)
    Synonyme
    GPRK7 Protein, MNK2 Protein, gprk7 Protein, mnk2 Protein, 2010016G11Rik Protein, Gprk7 Protein, Mnk2 Protein, mknk2 Protein, wu:fb37e05 Protein, wz5090 Protein, fi34c11 Protein, wu:fi34c11 Protein, wu:fi41e12 Protein, zgc:55587 Protein, MAP kinase interacting serine/threonine kinase 2 Protein, MAP kinase-interacting serine/threonine kinase 2 Protein, MAP kinase interacting serine/threonine kinase 2b Protein, MAP kinase interacting serine/threonine kinase 2 L homeolog Protein, MAP kinase interacting serine/threonine kinase 2a Protein, MKNK2 Protein, mknk2 Protein, Mknk2 Protein, mknk2b Protein, mknk2.L Protein, mknk2a Protein
    Hintergrund
    This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.
    Molekulargewicht
    46.5 kDa
    NCBI Accession
    NP_060042
    Pathways
    MAPK Signalweg
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