PAK1 Protein (Transcript Variant 1)

Produktnummer ABIN2728167

Produktdetails

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Antibody Production (AbP), Standard (STD), Functional Studies (Func), Protein Interaction (PI)

Spezifität: Optimal preservation of protein structure, post-translational modifications and functions.

Produktmerkmale:

• Recombinant human PAK1 (transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone
• Tested for bioactivity.

Reinheit: > 90 % as determined by SDS-PAGE and Coomassie blue staining

Endotoxin-Niveau: <0.1 ng/μg of protein (<1EU/μg).

Biological Activity Comment: Specific activity was determined as 32,638 pmoles/min/μg, according to the Zlyte assay protocol

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10 % glycerol, 5 mM DTT.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PAK1 (P21-Activated Kinase 1 (PAK1))

Andere Bezeichnung: Pak1 (PAK1 Produkte)

Synonyme: X-PAK1 Protein, XPak1 Protein, pak Protein, pak-1 Protein, pakalpha Protein, PAKalpha Protein, AW045634 Protein, PAK-1 Protein, Paka Protein, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog Protein, p21 (RAC1) activated kinase 1 Protein, p21 protein (Cdc42/Rac)-activated kinase 1 Protein, Serine/threonine-protein kinase pak-1 Protein, pak1.S Protein, PAK1 Protein, Pak1 Protein, pak-1 Protein

Hintergrund: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 33.6 kDa

NCBI Accession: NP_001122092

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis