ZIC2 Protein (ZIC2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2735883

Produktdetails

Target: ZIC2

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ZIC2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ZIC2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ZIC2

Andere Bezeichnung: Zic2 (ZIC2 Produkte)

Synonyme: HPE5 Protein, Ku Protein, cb851 Protein, fb26a03 Protein, wu:fb26a03 Protein, zic2 Protein, zic2.1 Protein, hpe5 Protein, hm:zeh0655 Protein, id:ibd5017 Protein, zic2.2 Protein, zic2l Protein, Zic family member 2 Protein, zinc finger protein of the cerebellum 2 Protein, zic family member 2 (odd-paired homolog, Drosophila), a Protein, Zic family member 2 L homeolog Protein, zic family member 2 (odd-paired homolog, Drosophila) b Protein, ZIC2 Protein, Zic2 Protein, zic2a Protein, zic2.L Protein, zic2b Protein

Hintergrund: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. [UniProtKB/Swiss-Prot Function]

Molekulargewicht: 54.8 kDa

NCBI Accession: NP_009060

Pathways: Tube Formation