FNDC5
(Fibronectin Type III Domain Containing 5 (FNDC5))
Protein-Typ
Recombinant
Proteineigenschaft
Extracellular Domain, AA 29-149
Spezies
Human, Maus, Ratte
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses FNDC5 Protein ist gelabelt mit Fc Tag.
Applikation
SDS-PAGE (SDS)
Kreuzreaktivität
Human, Maus, Ratte (Rattus)
Produktmerkmale
FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100 % identity between mouse, rat and human.
FRCP2 Protein, irisin Protein, 1500001L03Rik Protein, AI836596 Protein, C87088 Protein, PeP Protein, Pxp Protein, fndc5 Protein, si:dkey-264p5.1 Protein, zgc:158684 Protein, fibronectin type III domain containing 5 Protein, fibronectin type III domain containing 5b Protein, FNDC5 Protein, Fndc5 Protein, fndc5b Protein
Hintergrund
Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).