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AADAT Protein (His tag)

AADAT Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >97 % (SDS-PAGE) SDS
Produktnummer ABIN2745733
  • Target Alle AADAT Proteine anzeigen
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Protein-Typ
    Recombinant
    Spezies
    • 6
    • 1
    • 1
    • 1
    Human
    Quelle
    • 3
    • 2
    • 2
    • 2
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses AADAT Protein ist gelabelt mit His tag.
    Applikation
    SDS-PAGE (SDS)
    Kreuzreaktivität
    Human
    Produktmerkmale
    Human full-length KAT II is fused at the N-terminus to a His-tag.
    Reinheit
    >97 % (SDS-PAGE)
    Top Product
    Discover our top product AADAT Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In 50 mM phosphate buffer pH 8.0, containing 50 mM sodium chloride and 40μM pyridoxal 5'-phosphate (PLP).
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Short Term Storage: -20°C
    Long Term Storage: -80°C
    Stable for at least 6 months after receipt when stored at -80°C.
    Haltbarkeit
    6 months
  • Target
    AADAT (Aminoadipate Aminotransferase (AADAT))
    Andere Bezeichnung
    Kynurenine Aminotransferase II (AADAT Produkte)
    Synonyme
    KAT2 Protein, KATII Protein, AI875679 Protein, Aadt Protein, Kat2 Protein, mKat-2 Protein, MGC80030 Protein, kat2 Protein, katii Protein, aminoadipate aminotransferase Protein, aminoadipate aminotransferase S homeolog Protein, AADAT Protein, Aadat Protein, aadat.S Protein, aadat Protein
    Hintergrund
    Kynurenine aminotransferases (KATs) are pyridoxal-5'-phosphate-dependent enzymes that catalyze the conversion of L-kynurenine into kynurenic acid, a neuroactive metabolite whose unbalancing is associated with a number of brain disorders. Biochemical and structural investigations revealed that L-kynurenine (L-KYN) recognition by hKAT II is achieved by exploiting structural features that are peculiar of this isoform, thus offering the possibility to select/design inhibitor molecules specifically targeting hKAT II to be used as modulators of kynurenic acid synthesis in the CNS. hKAT II is one of the aminotransferases involved in the pyridoxal 5'-phosphate (PLP)-dependent irreversible transamination of L-kynurenine (L-KYN) to kynurenic acid (KYNA) in the central nervous system. When assayed in vitro the protein also displays beta-elimination activity.
    Molekulargewicht
    ~49.8kDa
    NCBI Accession
    NP_872603
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