Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MC4R Protein

MC4R Spezies: Human, Maus, Ratte Wirt: Escherichia coli (E. coli) Recombinant WB, PC
Produktnummer ABIN2746858
  • Target Alle MC4R Proteine anzeigen
    MC4R (Melanocortin 4 Receptor (MC4R))
    Protein-Typ
    Recombinant
    Spezies
    Human, Maus, Ratte
    Quelle
    • 2
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Applikation
    Western Blotting (WB), Positive Control (PC)
    Verwendungszweck
    Purified Protein in ready-to-use SDS sample buffer.
    Aufreinigung
    Purified Protein
    Top Product
    Discover our top product MC4R Protein
  • Applikationshinweise
    The sample is in ready-to-use buffer for application in SDS-PAGE and Western blotting.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    For 5 applications, volume varies from 100-200 μL in reduced SDS-PAGE sample buffer.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20 °C for long term storage
  • Target
    MC4R (Melanocortin 4 Receptor (MC4R))
    Andere Bezeichnung
    MC4 Receptor (MC4R Produkte)
    Synonyme
    zMC4 Protein, si:dkey-151m6.62 Protein, mc4r Protein, MC4R Protein, LOC100218148 Protein, Mc4-r Protein, melanocortin 4 receptor Protein, mc4r Protein, MC4R Protein, Mc4r Protein
    Hintergrund
    Melanocortin receptors are members of the rhodopsin family of 7-trans membrane G protein-coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. These receptors are activated by members of the Melanocortin family: alpha-, beta- and Gammamelanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The Melanocortins are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control. There are five melanocortin receptor subtypes each of which has a different pattern of tissue expression with the relative potency of different melanocortin peptides. The melanocortin signaling system consists of two endogenous antagonists that bind specifically to the receptor but instead of activating they have an inhibitory effect. The antagonist proteins are termed agouti (or agouti signaling protein, ASP) and agouti-related protein (AGRP). Melanocortin-4 receptor (MC4R) transcripts are expressed primarily in the brain. Genetic studies of mice and humans established a critical role of MC4R in appetite regulation. MC4R has been implicated in weight regulation and defects in this gene are a cause of autosomal dominant obesity. Activation of MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that obesity-linked gene, such as, MC4R is a potential candidate target for the treatment of obesity. Heterozygous mutations in MC4R account for 1-6 % of severe cases of human obesity. All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 40 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE. The gene for MC4R is present on chromosome 18q22.
    Molekulargewicht
    40 kDa
    NCBI Accession
    NP_005903
    UniProt
    P32245
    Pathways
    Hormone Transport, cAMP Metabolic Process, Feeding Behaviour
Sie sind hier:
Kundenservice