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Pleiotrophin Protein (PTN)

PTN Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >96 % as determined by SDS-PAGE and HPLC. Func Active
Produktnummer ABIN2830304
  • Target Alle Pleiotrophin (PTN) Proteine anzeigen
    Pleiotrophin (PTN)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Quelle
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Applikation
    Functional Studies (Func)
    Sequenz
    GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
    Produktmerkmale
    Biological Activity: Fully biologically active when compared to standard. The biological activity was measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been pre-coated wi
    Reinheit
    >96 % as determined by SDS-PAGE and HPLC.
    Sterilität
    0.2 μm filtered
    Top Product
    Discover our top product PTN Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Lagerung
    -20 °C
  • Target
    Pleiotrophin (PTN)
    Andere Bezeichnung
    PTN (PTN Produkte)
    Synonyme
    zHBNF Protein, zgc:111787 Protein, harp Protein, hbnf Protein, X-PTF Protein, hbgf8 Protein, negf1 Protein, ptn Protein, PTN Protein, HARP Protein, HBGF8 Protein, HBNF Protein, NEGF1 Protein, PTN-A Protein, HB-GAM Protein, HBBM Protein, HBGF-8 Protein, OSF-1 Protein, HBBN Protein, OSF Protein, Osf-1 Protein, Osf1 Protein, Hbnf Protein, pleiotrophin Protein, pleiotrophin L homeolog Protein, ptn Protein, PTN Protein, ptn.L Protein, Ptn Protein
    Hintergrund
    Relevance: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.
    Synonyms: PTN, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule
    Molekulargewicht
    15.3 kDa
    UniProt
    P21246
    Pathways
    RTK Signalweg
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