TNFSF4
(Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (TNFSF4))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 51-183
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses TNFSF4 Protein ist gelabelt mit His tag.
Sequenz
AA 51-183
Produktmerkmale
This protein carries a polyhistidine tag at the N-terminus, and has a calculated MW of 16.9 kDa. The predicted N-terminus is His. The reducing (R) protein migrates as 25-30 kDa in SDS-PAGE due to glycosylation.
TNFSF4
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
FACS
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46 % amino acid sequence identity with its mouse counterpart.