ACVA Protein (AA 311-426)

Produktnummer ABIN4369364

Produktdetails

Target: ACVA (Activin A (ACVA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 311-426

Spezies: Human

Quelle: HEK-293 Cells

Marke: ActiveMax®

Sequenz: AA 311-426

Produktmerkmale: This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 0.1 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.056 % TFA in 60 % ACN

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution

Referenzen

Basu, Bhattacharya, Ray, Mukhopadhyay, Chatterjee, Roy: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).

Antigendetails

Target: ACVA (Activin A (ACVA))

Andere Bezeichnung: Activin A /INHBA (ACVA Produkte)

Synonyme: inhibin beta A subunit Protein, Inhba Protein

Hintergrund: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.

Molekulargewicht: 13.0 kDa

Pathways: Hormone Transport, Peptide Hormone Metabolism