Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag)
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- Target Alle Transferrin Receptor 2 (TFR2) Proteine anzeigen
- Transferrin Receptor 2 (TFR2)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 103-798
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Transferrin Receptor 2 Protein ist gelabelt mit Fc Tag.
- Applikation
- Functional Studies (Func)
- Sequenz
- AA 103-798
- Produktmerkmale
- This protein carries a mouse IgG1 Fc tag at the N-terminus, and has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 0.1 EU per μg by the LAL method.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
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-
Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
: "
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Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).
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- Target
- Transferrin Receptor 2 (TFR2)
- Andere Bezeichnung
- Transferrin R2 (TFR2 Produkte)
- Synonyme
- TFR2 Protein, Trfr2 Protein, HFE3 Protein, TFRC2 Protein, zgc:123043 Protein, transferrin receptor 2 Protein, TFR2 Protein, Tfr2 Protein, tfr2 Protein
- Hintergrund
- Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
- Molekulargewicht
- 101.1 kDa
- NCBI Accession
- NP_056614
- UniProt
- Q9JKX3
- Pathways
- Transition Metal Ion Homeostasis
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