TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
Protein-Typ
Recombinant
Biologische Aktivität
Active
Proteineigenschaft
AA 17-138
Spezies
Ratte
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses TIGIT Protein ist gelabelt mit Fc Tag.
Applikation
Functional Studies (Func)
Sequenz
AA 17-138
Produktmerkmale
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40 kDa. As a result of glycosylation, the protein migrates as 48-55 kDa under reducing (R) condition, and 85-110 kDa under non-reducing (NR) condition (SDS-PAGE).
TIGIT
Spezies: Cynomolgus
Wirt: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
Tris with Glycine, Arginine and NaCl, pH 7.5
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Target
TIGIT
(T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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Hintergrund
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.