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HMOX2 Protein (full length)

HMOX2 Spezies: Ratte Wirt: Ratte Native >90% pure using SDS - PAGE analysis. SDS, WB
Produktnummer ABIN5021766
  • Target Alle HMOX2 Proteine anzeigen
    HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))
    Protein-Typ
    Native
    Proteineigenschaft
    full length
    Spezies
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Quelle
    • 6
    • 5
    • 3
    • 1
    Ratte
    Applikation
    SDS-PAGE (SDS), Western Blotting (WB)
    Sequenz
    MSSEVETSEG VDESENNSTA PEKENHTKMA DLSELLKEGT KEAHDRAENT QFVKDFLKGN IKKELFKLAT TALYFTYSAL EEEMDRNKDH PAFAPLYFPT ELHRKEALIK DMEYFFGENW EEQVKCSEAA QKYVDRIHYV GQNEPELLVA HAYTRYMGDL SGGQVLKKVA QRALKLPSTG EGTQFYLFEH VDNAQQFKQF YRARMNALDL SMKTKERIVE EANKAFEYNM QIFSELDQAG SMLTKETLED GLPVHDGKGD VRKCPFYAAQ PDKGTLGGSN CPFRTAMAVL RKPSLQLILA ASVALVAGLL AWYYM
    Spezifität
    ~36 kDa
    Aufreinigung
    Ion-exchange Purified
    Reinheit
    >90% pure using SDS - PAGE analysis.
    Top Product
    Discover our top product HMOX2 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    This product has been certified >90% pure using SDS - PAGE analysis.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    Lot specific
    Buffer
    20 mM Tris pH 7.5, 0.1 mM EDTA, 0.25 % Na cholate, <20 mM KCl
    Lagerung
    -80 °C
  • Target
    HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))
    Andere Bezeichnung
    HO-2 (HMOX2 Produkte)
    Synonyme
    HO-2 Protein, HO2 Protein, HMOX2 Protein, Ho-2 Protein, im:6909100 Protein, si:dkey-44g23.7 Protein, AtHO2 Protein, T9J22.22 Protein, T9J22_22 Protein, heme oxygenase 2 Protein, hmox2 Protein, ho-2 Protein, heme oxygenase 2 Protein, Heme oxygenase 2 Protein, heme oxygenase 2, putative Protein, heme oxygenase 2a Protein, heme oxygenase 2 L homeolog Protein, HMOX2 Protein, Hmox2 Protein, HO2 Protein, ho2 Protein, CNF01200 Protein, CPR_0203 Protein, CGB_F5120W Protein, hmox2a Protein, hmox2.L Protein
    Hintergrund
    Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator, biliverdin and bilirubin are potent antioxidants, and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3, however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).
    Gen-ID
    79239
    NCBI Accession
    NP_077363
    UniProt
    P23711
    Pathways
    Transition Metal Ion Homeostasis
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