LILRB4
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))
Protein-Typ
Recombinant
Proteineigenschaft
AA 22-259
Spezies
Cynomolgus
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses LILRB4 Protein ist gelabelt mit His tag.
Sequenz
AA 22-259
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.0 kDa. The protein migrates as 38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
LILRB4
Spezies: Human
Wirt: Mammalian Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
PBS, pH 7.4
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Target
LILRB4
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))
CD85K Protein, ILT-3 Protein, ILT3 Protein, LIR-5 Protein, LIR5 Protein, Gp49b Protein, HM18 Protein, gp49 Protein, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 Protein, leukocyte immunoglobulin like receptor B4 Protein, leukocyte immunoglobulin-like receptor, subfamily B, member 4A Protein, LILRB4 Protein, Lilrb4a Protein
Hintergrund
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.