Granulin Protein (GRN) (AA 1-593)

Produktnummer ABIN5564456

Produktdetails

Target: Granulin (GRN)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 1-593

Spezies: Human

Quelle: HEK-293 Cells

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Human

Produktmerkmale: Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Solid

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: Granulin (GRN)

Andere Bezeichnung: Progranulin (GRN Produkte)

Synonyme: GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein

Substanzklasse: Viral Protein

Hintergrund: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Molekulargewicht: ~74kDa (glycosylated protein by SDS-PAGE)

UniProt: P28799