Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.1-2 mg/mL
Buffer
20 mM Tris-HCl based buffer, pH 8.0
Lagerung
-80 °C,4 °C,-20 °C
Informationen zur Lagerung
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target
RAB5 (RAB5A)
(RAB5A, Member RAS Oncogene Family (RAB5A))
RAB5 Protein, 2410015H04Rik Protein, AI663973 Protein, AU021172 Protein, nnyRab5a Protein, DDBDRAFT_0168594 Protein, DDBDRAFT_0229401 Protein, DDB_0168594 Protein, DDB_0229401 Protein, rab5 Protein, RAB5A Protein, Rab5a Protein, rab5al Protein, zgc:56644 Protein, fj38g08 Protein, hm:zehn1144 Protein, rab5a Protein, wu:fj38g08 Protein, RAB5A, member RAS oncogene family Protein, rab5A protein Protein, Rab5a, GTPase Protein, predicted protein Protein, Rab GTPase Protein, RAB5A, member RAS oncogene family L homeolog Protein, RAB5A, member RAS oncogene family, b Protein, RAB5A, member RAS oncogene family, a Protein, RAB5A Protein, Rab5a Protein, rab5A Protein, rab5a Protein, rab5a.L Protein, rab5ab Protein, rab5aa Protein
Hintergrund
The small GTPases Rab are key regulators of intracellular mbrane trafficking, from the formation of transport vesicles to their fusion with mbranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to mbranes different sets of downstream effectors directly responsible for vesicle formation, movent, tethering and fusion. RAB5A is required for the fusion of plasma mbranes and early endosomes. Contributes to the regulation of filopodia extension.