Angiopoietin 1 Protein (ANGPT1) (AA 16-498) (His tag)

Produktnummer ABIN5711317

Produktdetails

Target: Angiopoietin 1 (ANGPT1)

Protein-Typ: Recombinant

Proteineigenschaft: AA 16-498

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Angiopoietin 1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: HIGCSNQRRS PENSGRRYNR IQHGQCAYTF ILPEHDGNCR ESTTDQYNTN ALQRDAPHVE PDFSSQKLQH LEHVMENYTQ WLQKLENYIV ENMKSEMAQI QQNAVQNHTA TMLEIGTSLL SQTAEQTRKL TDVETQVLNQ TSRLEIQLLE NSLSTYKLEK QLLQQTNEIL KIHEKNSLLE HKILEMEGKH KEELDTLKEE KENLQGLVTR QTYIIQELEK QLNRATTNNS VLQKQQLELM DTVHNLVNLC TKEGVLLKGG KREEEKPFRD CADVYQAGFN KSGIYTIYIN NMPEPKKVFC NMDVNGGGWT VIQHREDGSL DFQRGWKEYK MGFGNPSGEY WLGNEFIFAI TSQRQYMLRI ELMDWEGNRA YSQYDRFHIG NEKQNYRLYL KGHTGTAGKQ SSLILHGADF STKDADNDNC MCKCALMLTG GWWFDACGPS NLNGMFYTAG QNHGKLNGIK WHYFKGPSYS LRSTTMMIRP LDF

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Angiopoietin 1 (ANGPT1)

Andere Bezeichnung: ANGP1 (ANGPT1 Produkte)

Synonyme: AGP1 Protein, AGPT Protein, ANG1 Protein, 1110046O21Rik Protein, Ang-1 Protein, Ang1 Protein, Agpt Protein, Agpt1 Protein, ang1 Protein, wu:fc76g06 Protein, ANG-1 Protein, angpt1 Protein, MGC80788 Protein, angiopoietin 1 Protein, angiopoietin 1 S homeolog Protein, ANGPT1 Protein, Angpt1 Protein, angpt1 Protein, angpt1.S Protein

Hintergrund: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during bryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Molekulargewicht: 60 kDa

UniProt: Q15389

Pathways: RTK Signalweg, Glycosaminoglycan Metabolic Process