Caspase 3 Protein (CASP3) (AA 29-175, partial) (His tag)

Produktnummer ABIN5712415

Produktdetails

Target: Caspase 3 (CASP3)

Protein-Typ: Recombinant

Proteineigenschaft: partial, AA 29-175

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Caspase 3 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SGISLDNSYK MDYPEMGLCI IINNKNFHKS TGMTSRSGTD VDAANLRETF RNLKYEVRNK NDLTREEIVE LMRDVSKEDH SKRSSFVCVL LSHGEEGIIF GTNGPVDLKK ITNFFRGDRC RSLTGKPKLF IIQACRGTEL DCGIETD

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Caspase 3 (CASP3)

Andere Bezeichnung: CASP3 (CASP3 Produkte)

Synonyme: CPP32 Protein, CPP32B Protein, SCA-1 Protein, A830040C14Rik Protein, AC-3 Protein, Apopain Protein, CC3 Protein, Caspase-3 Protein, Lice Protein, Yama Protein, mldy Protein, xcpp32 Protein, casp3 Protein, zgc:100890 Protein, CASP-3 Protein, caspase-3 Protein, caspase 3 Protein, caspase 3 S homeolog Protein, caspase 3, apoptosis-related cysteine peptidase a Protein, caspase 3, apoptosis-related cysteine peptidase Protein, CASP3 Protein, Casp3 Protein, casp3.S Protein, casp3a Protein

Hintergrund: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory elent binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the mbrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Molekulargewicht: 20.7 kDa

UniProt: P42574

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation