Background: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization By similarity. Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. Ref.15 Medin is the main constituent of aortic medial amyloid. Synonyms: Breast epithelial antigen BA46 HMFG MFGM Milk fat globule-EGF factor 8 Short name=MFG-E8 SED1 Cleaved into the following 2 chains: Lactadherin short form Medin.