Sema4a Protein (AA 1-676) (Fc Tag)
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- Target Alle Sema4a Proteine anzeigen
- Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-676
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Spezies
- Maus
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Quelle
- CHO Cells
- Aufreinigungstag / Konjugat
- Dieses Sema4a Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Semaphorin-4A (mouse):Fc (human) (rec.)
- Spezifität
- The extracellular domain of mouse Semaphorin-4A (aa 1-676) is fused to the N-terminus of the Fc region of human IgG1.
- Produktmerkmale
- Protein. The extracellular domain of mouse Semaphorin-4A (aa 1-676) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM2 (T cell immunoglobulin and mucin domain 2). Mice with targeted disruption of Sema4A show defects in dendritic cellmediated T cell priming and Th1 responses. Roles for Sema4A have also been identified in the brain, the endothelium and the eye. It mediates hippocampal neuron growth cone collapse in vitro through interaction of the sema domain with plexinB1. Interaction of Sema4A with endothelial cell plexinD1 causes opposition to the angiogenic, proliferative, chemotactic and integrin mediated adhesive actions of VEGF.
- Reinheit
- >98 % (SDS-PAGE)
- Endotoxin-Niveau
- <0.06EU/μg protein (LAL test, Lonza).
- Top Product
- Discover our top product Sema4a Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Konzentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handhabung
- Avoid freeze/thaw cycles.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- Sema4a (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))
- Andere Bezeichnung
- Semaphorin-4A (Sema4a Produkte)
- Synonyme
- SEMA4A Protein, CORD10 Protein, RP35 Protein, SEMAB Protein, SEMB Protein, AI132332 Protein, SemB Protein, Semab Protein, semaphorin 4A Protein, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A Protein, SEMA4A Protein, sema4a Protein, Sema4a Protein
- Hintergrund
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Alternate Names/Synonyms: Sema4a, Semaphorin-B, Sema B
Product Description: Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM2 (T cell immunoglobulin and mucin domain 2). Mice with targeted disruption of Sema4A show defects in dendritic cellmediated T cell priming and Th1 responses. Roles for Sema4A have also been identified in the brain, the endothelium and the eye. It mediates hippocampal neuron growth cone collapse in vitro through interaction of the sema domain with plexinB1. Interaction of Sema4A with endothelial cell plexinD1 causes opposition to the angiogenic, proliferative, chemotactic and integrin mediated adhesive actions of VEGF.
- NCBI Accession
- NP_038686
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