PRKAB1 Protein (His tag)
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- Target Alle PRKAB1 Proteine anzeigen
- PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses PRKAB1 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Aufreinigung
- purified by chromatography
- Reinheit
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product PRKAB1 Protein
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- Kommentare
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Synonyms: 5'-AMP-activated protein kinase subunit beta-1, AMPK, HAMPKb
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol, 1 MM DTT
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Avoid repeated freezing and thawing cycles.
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- Target
- PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))
- Andere Bezeichnung
- PRKAB1 (PRKAB1 Produkte)
- Synonyme
- AMPK Protein, HAMPKb Protein, 1300015D22Rik Protein, AU021155 Protein, E430008F22 Protein, MGC82489 Protein, prkab1 Protein, wu:fk93d05 Protein, wu:fw87e09 Protein, zgc:56652 Protein, zgc:76975 Protein, zgc:92228 Protein, protein kinase AMP-activated non-catalytic subunit beta 1 Protein, protein kinase, AMP-activated, beta 1 non-catalytic subunit Protein, protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog Protein, protein kinase, AMP-activated, beta 1 non-catalytic subunit, b Protein, protein kinase, AMP-activated, beta 1 non-catalytic subunit, a Protein, PRKAB1 Protein, Prkab1 Protein, prkab1.S Protein, prkab1 Protein, prkab1b Protein, prkab1a Protein
- Hintergrund
- 5'-AMP-activated protein kinase subunit beta-1, also known as PRKAB1, inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Recombinant human PRKAB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molekulargewicht
- 32.8 kDa (293aa) confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
- NCBI Accession
- NP_006244
- Pathways
- AMPK Signaling, Warburg Effekt
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