PEPC Protein, PGII Protein, 2210410L06Rik Protein, Upg-1 Protein, Upg1 Protein, CPGC Protein, gastricsin Protein, PG1 Protein, Pg-1 Protein, PGNC Protein, PGC Protein, Gastricsin Protein, progastricsin (pepsinogen C) Protein, progastricsin Protein, PGC Protein, Pgc Protein
Hintergrund
PGC, also known as gastricsin, is an aspartic proteinase that belongs to the peptidase family A1. It is synthesized in the gastric mucosa as inactive precursors. It contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. Serum levels of PGC are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Recombinant human PGC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Molekulargewicht
41.6kDa (380aa) 40-57kDa (SDS-PAGE under reducing conditions)