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Chromogranin A Protein (CHGA) (AA 19-457) (His tag)
CHGA
Spezies: Human
Wirt: Baculovirus infected Insect Cells
Recombinant
> 85 % by SDS - PAGE
SDS
Produktnummer ABIN7529384
Produktdetails
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Target
Alle Chromogranin A (CHGA) Proteine anzeigen
Chromogranin A (CHGA)
Protein-Typ
Recombinant
Proteineigenschaft
AA 19-457
Spezies
Alle Spezies für Chromogranin A Proteine
Human
Quelle
Alle Expressionssysteme für Chromogranin A Proteine
Baculovirus infected Insect Cells
Aufreinigungstag / Konjugat
Dieses Chromogranin A Protein ist gelabelt mit His tag.
Applikation
SDS-PAGE (SDS)
Sequenz
ADLLPVNSPM NKGDTEVMKC IVEVISDTLS KPSPMPVSQE CFETLRGDER ILSILRHQNL LKELQDLALQ GAKERAHQQK KHSGFEDELS EVLENQSSQA ELKEAVEEPS SKDVMEKRED SKEAEKSGEA TDGARPQALP EPMQESKAEG NNQAPGEEEE EEEEATNTHP PASLPSQKYP GPQAEGDSEG LSQGLVDREK GLSAEPGWQA KREEEEEEEE EAEAGEEAVP EEEGPTVVLN PHPSLGYKEI RKGESRSEAL AVDGAGKPGA EEAQDPEGKG EQEHSQQKEE EEEMAVVPQG LFRGGKSGEL EQEEERLSKE WEDSKRWSKM DQLAKELTAE KRLEGQEEEE DNRDSSMKLS FRARAYGFRG PGPQLRRGWR PSSREDSLEA GLPLQVRGYP EEKKEEEGSA NRRPEDQELE SLSAIEAELE KVAHQLQALR RGHHHHHH
Reinheit
> 85 % by SDS - PAGE
Endotoxin-Niveau
< 1.0 EU per 1ug of protein (determined by LAL method)
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Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
0.25 mg/mL
Buffer
Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 20 % glycerol, 0.1 mM PMSF
Lagerung
4 °C,-20 °C,-80 °C
Informationen zur Lagerung
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Antigendetails
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Target
Chromogranin A (CHGA)
Andere Bezeichnung
CHGA (CHGA Produkte )
Synonyme
CGA Protein, CG-ALPHA Protein, FSHA Protein, GPHA1 Protein, GPHa Protein, HCG Protein, LHA Protein, TSHA Protein, ChrA Protein, fj05f09 Protein, si:dkey-177p2.2 Protein, wu:fj05f09 Protein, zgc:101749 Protein, zgc:56075 Protein, CHGA Protein, cgA Protein, chga Protein, chromogranin A Protein, glycoprotein hormones, alpha polypeptide Protein, uncharacterized CHGA Protein, chromogranin A S homeolog Protein, CHGA Protein, CGA Protein, Chga Protein, chga Protein, chga.S Protein
Hintergrund
CHGA, also known as chromogranin-A isoform 1 preproprotein, is a member of neuroendocrine secretory proteins of the chromogranin / secretogranin family. It is a precursor of several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. This peptide negatively regulates the neuroendocrine function of autocrine or nearby cells (paracrine). This protein induces and promotes the production of secretory granules containing insulin in pancreatic islet beta cells. Recombinant human CHGA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Molekulargewicht
50kDa (448aa) 50-70kDa (SDS-PAGE under reducing conditions)
NCBI Accession
NP_001266
UniProt
P10645
Pathways
Negative Regulation of Hormone Secretion , cAMP Metabolic Process , Regulation of G-Protein Coupled Receptor Protein Signaling
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