14-3-3 sigma/SFN Protein (AA 1-248)
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- Target Alle 14-3-3 sigma/SFN (SFN) Proteine anzeigen
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-248
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Applikation
- SDS-PAGE (SDS)
- Produktmerkmale
- 14-3-3 sigma, 1-248aa, Human, E.coli
- Reinheit
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product SFN Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol
- Lagerung
- 4 °C
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- Target
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Andere Bezeichnung
- 14-3-3 sigma (SFN Produkte)
- Synonyme
- YWHAS Protein, Er Protein, Mme1 Protein, Ywhas Protein, stratifin Protein, SFN Protein, Sfn Protein
- Hintergrund
- 14-3-3 sigma ,also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: stratifin, Epithelial cell marker protein 1, HME1, YWHAS, SFN, 14-3-3 sigma. NCBI no.: NP_006133
- Molekulargewicht
- 27.7 kDa (248aa), confirmed by MALDI-TOF.
- Pathways
- p53 Signalweg, Myometrial Relaxation and Contraction
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