Carbonic anhydrase 2 (CA2) is one of fourteen forms of human alpha carbonic anhydrases. Carbonic anhydrase catalyzes reversible hydration of carbon dioxide. CA2 is a cytosolic enzyme with the highest activity among all known CAs. Mutations in the CA2 gene result in the CA2 deficiency syndrome, an autosomal recessive disorder that produces osteopetrosis, renal tubular acidosis and cerebral calcification. Recombinant human CA2 was expressed in E.coli and purified by using conventional chromatography. Synonyms: Carbonic anhydrase 2, CA-II, CAC, CA 2, CA II, CA2, CAI, Car 2, Car2, Carbonate dehydratase II, Carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, Carbonic dehydratase. NCBI no.: NP_000058