SIRT6 Protein (GST tag)
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- Target Alle SIRT6 Proteine anzeigen
- SIRT6 (Sirtuin 6 (SIRT6))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses SIRT6 Protein ist gelabelt mit GST tag.
- Applikation
- Western Blotting (WB)
- Hersteller Produkt- Nr.
- 009-001-t36s
- Hersteller
- Rockland
- Verwendungszweck
- SIRT6 recombinant protein-GST fusion protein
- Aufreinigung
- Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-Terminal Glutathione-S-Transferase fusion protein. The purity was determined to be >85% by densitometry.
- Reinheit
- >85%
- Top Product
- Discover our top product SIRT6 Protein
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- Applikationshinweise
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Western_Blot_Dilution: User Optimized
Application_Note: SIRT6 Protein is suitable for use in Western Blot. Expect a band approximately ~66 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.2 μg/μL
- Buffer
- SIRT6 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- SIRT6 (Sirtuin 6 (SIRT6))
- Andere Bezeichnung
- SIRT6 (SIRT6 Produkte)
- Hintergrund
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Synonyms: SIR2L6, Sirtuin 6, NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, SIR2-like protein 6, SIRT6, SIR2L6
Background: SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2). SIRT6 Protein is ideal for investigators involved in Signaling Proteins, Cancer, Cell Cycle, and Inflammation research.
- NCBI Accession
- NM_016539
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