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tau Protein (full length, Pro301Ser-Mutant)

Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active
Produktnummer ABIN6929397
  • Target Alle tau Proteine anzeigen
    tau (tau Protein)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    Pro301Ser-Mutant, full length
    Spezies
    • 10
    • 3
    • 1
    • 1
    Human
    Quelle
    • 14
    • 1
    Escherichia coli (E. coli)
    Applikation
    SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
    Verwendungszweck
    Active Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils
    Sequenz
    MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV SGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
    Spezifität
    ~45.8 kDa
    Aufreinigung
    Ion-exchange Purified
    Biological Activity Comment
    Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
    Top Product
    Discover our top product tau Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    Lot specific
    Buffer
    10 mM HEPES, 100 mM NaCl pH 7.4
    Lagerung
    -80 °C
  • Target
    tau (tau Protein)
    Andere Bezeichnung
    Tau (tau Produkte)
    Synonyme
    DDPAC Protein, FTDP-17 Protein, MAPTL Protein, MSTD Protein, MTBT1 Protein, MTBT2 Protein, PPND Protein, TAU Protein, tau Protein, PHF-tau Protein, microtubule associated protein tau Protein, MAPT Protein
    Hintergrund
    Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).
    NCBI Accession
    NP_005901
    UniProt
    P10636
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