CCL2 Protein (AA 24-99) (Biotin)

Produktnummer ABIN6952161

Produktdetails

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 24-99

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CCL2 Protein ist gelabelt mit Biotin.

Applikation: Cell Migration Assay (CMA), Flow Cytometry (FACS)

Sequenz: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSIDHLDKQ TQTPKT

Produktmerkmale: Biotininylated Recombinant Human CCL2 (MCP-1)

Reinheit: > 97 % by SDS PAGE

Endotoxin-Niveau: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 0.25-1.2 nM determined by Migration Assay of recombinant CCR2 containing cells

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Haltbarkeit: 12 months

Antigendetails

Target: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Andere Bezeichnung: CCL2 (MCP-1) (CCL2 Produkte)

Synonyme: GDCF-2 Protein, HC11 Protein, HSMCR30 Protein, MCAF Protein, MCP-1 Protein, MCP1 Protein, SCYA2 Protein, SMC-CF Protein, AI323594 Protein, JE Protein, Scya2 Protein, Sigje Protein, MCP-1A Protein, MCP1A Protein, C-C motif chemokine ligand 2 Protein, chemokine (C-C motif) ligand 2 Protein, C-C motif chemokine 2 Protein, CCL2 Protein, Ccl2 Protein, LOC101120093 Protein

Hintergrund: Monocyte chemoattractant protein-1 (MCP-1) (CCL2) is produced by many cell types at sites of inflammation. It regulates chemotaxis and transendothielial migration of monocytes, as well as memory T cells and natural killer cells by interacting with their membrane surface receptor CCR2. MCP-1 has also been implicated in a number of disease states, such as rheumatoid arthritis, psoriasis, atherosclerosis, autoimmune diseases, tumor progression, and HIV infection. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It binds to chemokine receptors CCR2 and CCR4.

Molekulargewicht: 11.085 kDa

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion