CCL4
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 97 % by SDS-PAGE.
Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
Lagerung
-20 °C,-80 °C
Informationen zur Lagerung
12 months from date of receipt, -20 to -70 °C as supplied. Suggest to use immediately after reconstitution 1 month at -20 to -70 °C under sterile conditions after reconstitution.
Monokine with inflammatory and chemokinetic properties binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta (3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.