CXCL10 Protein (AA 22-98)

Produktnummer ABIN6952220

Recombinant CXCL10-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für CXCL10 Protein (AA 22-98) (ABIN6952220)

Target: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Cell Migration Assay (CMA)

Produktdetails

Proteineigenschaft: AA 22-98

Sequenz: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Produktmerkmale: Recombinant Human CXCL10 (IP-10)

Endotoxin-Niveau: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 6.3 nM determined by Migration Assay in cells expressing recombinant CXCR3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Haltbarkeit: 12 months

Antigendetails

Target: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Andere Bezeichnung: CXCL10 (IP-10)

Hintergrund: CXCL10 (IP-10) was originally identified as an IFN-gamma-inducible gene in endothelial, fibroblasts and monocytes cells. IP-10 is considered a member of the CXC chemokine subfamily from its protein sequence which includes the four conserved cysteine residues present in CXC chemokines. IP-10 signals through the CXCR3 receptor to selectively attract Th1 lymphocytes and monocytes. It also has angiostatic and mitogenic properties on vascular smooth muscle cells. A diverse population of cell types rapidly increases transcription of mRNA encoding IP-10, which suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Molekulargewicht: 8.646 kDa

UniProt: P02778