C5 Protein (AA 19-1678) (His tag)
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- Target Alle C5 Proteine anzeigen
- C5 (Complement Component 5 (C5))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 19-1678
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Spezies
- Kaninchen
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses C5 Protein ist gelabelt mit His tag.
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product C5 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Lagerung
- -20 °C
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- Target
- C5 (Complement Component 5 (C5))
- Andere Bezeichnung
- Complement C5 (C5 Produkte)
- Synonyme
- C5 Protein, LOC565774 Protein, C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, He Protein, complement C5 Protein, complement component 5 Protein, hemolytic complement Protein, C5 Protein, c5 Protein, Hc Protein
- Hintergrund
- Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
- Molekulargewicht
- 73.8 kDa (β chain) & 111.9 kDa (α chain)
- NCBI Accession
- XP_008271599
- Pathways
- Komplementsystem, Carbohydrate Homeostasis
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