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SARS-CoV-2 Spike S2 Protein (His tag)

Spezies: SARS Coronavirus-2 (SARS-CoV-2) Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. SDS
Produktnummer ABIN6952626
  • Target Alle SARS-CoV-2 Spike S2 Proteine anzeigen
    SARS-CoV-2 Spike S2
    Protein-Typ
    Recombinant
    Spezies
    • 16
    • 3
    • 1
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    Quelle
    • 13
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses SARS-CoV-2 Spike S2 Protein ist gelabelt mit His tag.
    Applikation
    SDS-PAGE (SDS)
    Verwendungszweck
    SARS-CoV-2 (COVID-19) S2 protein, His Tag
    Sequenz
    AA 686-1213
    Produktmerkmale
    SARS-CoV-2 S2 protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1). Predicted N-terminus: Ser 686
    This protein carries a polyhistidine tag at the C-terminus.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product SARS-CoV-2 Spike S2 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    For long term storage, the product should be stored at lyophilized state at -20°C or lower.
    This product is stable after storage at:
    4-8°C for 12 months in lyophilized state,
    -70°C for 3 years under sterile conditions after reconstitution.
  • Longworth, Dittmar: "An antigen microarray protocol for COVID-19 serological analysis." in: STAR protocols, Vol. 2, Issue 3, pp. 100815, (2021) (PubMed).

    Tosif, Neeland, Sutton, Licciardi, Sarkar, Selva, Do, Donato, Quan Toh, Higgins, Van de Sandt, Lemke, Lee, Shoffner, Flanagan, Arnold, Mordant, Mulholland, Bines, Dohle, Pellicci, Curtis, McNab et al.: "Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19. ..." in: Nature communications, Vol. 11, Issue 1, pp. 5703, (2020) (PubMed).

    Wei, Wan, Yan, Wang, Zhang, Yang, Zhang, Fan, Li, Deng, Sun, Gong, Yang, Wang, Wang, Li, Yang, Li, Zhang, Wang, Du, Zong, Yin, Zhang, Wang, Peng, Lin, Feng, Qin, Chen, Gao, Zhang, Cao, Zhong: "HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry." in: Nature metabolism, Vol. 2, Issue 12, pp. 1391-1400, (2020) (PubMed).

  • Target
    SARS-CoV-2 Spike S2
    Abstract
    SARS-CoV-2 Spike S2 Produkte
    Synonyme
    E2 Protein, Surface Glycoprotein Protein, S Protein
    Substanzklasse
    Viral Protein
    Hintergrund
    It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Molekulargewicht
    60.0 kDa
    Gen-ID
    43740568
    UniProt
    P0DTC2
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