MICA Protein (AA 24-307) (His tag)
-
- Target Alle MICA Proteine anzeigen
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 24-307
-
Spezies
- Human
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses MICA Protein ist gelabelt mit His tag.
- Applikation
- ELISA
- Verwendungszweck
- Recombinant Human MICA Protein with C-terminal 6xHis tag
- Spezifität
- MICA (Glu24-Trp307) 6xHis tag
- Produktmerkmale
- Extracellular Domain Protein
- Aufreinigung
- Purified from cell culture supernatant by affinity chromatography
- Reinheit
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product MICA Protein
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Haltbarkeit
- 12 months
-
- Target
- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
- Andere Bezeichnung
- MICA (MICA Produkte)
- Synonyme
- MIC-A Protein, PERB11.1 Protein, MHC class I polypeptide-related sequence A Protein, MICA Protein
- Hintergrund
- This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
- Molekulargewicht
- predicted molecular mass of 33.5 kDa after removal of the signal peptide. The apparent molecular mass of MICA-His is 55-70 kDa due to glycosylation.
- Gen-ID
- 100507436
- UniProt
- Q29983
- Pathways
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
-