NLRP3 Protein (AA 2-1036) (DYKDDDDK Tag)

Produktnummer ABIN6964301

Produktdetails

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-1036

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NLRP3 Protein ist gelabelt mit DYKDDDDK Tag.

Verwendungszweck: Recombinant Human NLRP3 with C-terminal Flag tag

Spezifität: NLRP3 (Lys2-Trp1036) Flag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Andere Bezeichnung: NLRP3 (NLRP3 Produkte)

Synonyme: CIAS1 Protein, Nalp3 Protein, avp Protein, cias1 Protein, nalp3 Protein, pypaf1 Protein, agtavprl Protein, AGTAVPRL Protein, AII Protein, AVP Protein, C1orf7 Protein, CLR1.1 Protein, FCAS Protein, FCU Protein, MWS Protein, NALP3 Protein, PYPAF1 Protein, AII/AVP Protein, Cias1 Protein, Mmig1 Protein, Pypaf1 Protein, NLR family pyrin domain containing-like Protein, NLR family pyrin domain containing 3 Protein, NLR family, pyrin domain containing 3 L homeolog Protein, NLR family, pyrin domain containing 3 Protein, NLRPL Protein, NLRP3 Protein, nlrp3.L Protein, Nlrp3 Protein

Hintergrund: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Molekulargewicht: predicted molecular mass of 121.8 kDa after removal of the signal peptide.

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome