Dieses SARS-CoV-2 Nucleocapsid Protein ist gelabelt mit His tag.
Verwendungszweck
SARS-CoV-2 Nucleocapsid protein (T205I), His Tag
Sequenz
AA 1-419
Produktmerkmale
SARS-CoV-2 Nucleocapsid protein (T205I), His Tag is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419 (Accession # QHO62115.1 (T205I). The nucleocapsid protein is consisted of the N-terminal RNA-binding domain (NTD) and the C-terminal dimerization domain (CTD), divided by a central serine/arginine-rich (SR)-linker responsible for phosphorylation. The mutation T205I was identified on the nucleocapsid protein of SARS-CoV-2 variants with high frequency in B.1.351 variants circulating in South Africa.
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.