NOTCH2 Protein (AA 26-530) (Fc Tag)
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- Target Alle NOTCH2 Proteine anzeigen
- NOTCH2 (Notch 2 (NOTCH2))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 26-530
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses NOTCH2 Protein ist gelabelt mit Fc Tag.
- Produktmerkmale
- Human NOTCH2 Protein, Fc Tag (MALS verified)
- Reinheit
- >95 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH2 Protein
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- Applikationshinweise
- MALS verified
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Lagerung
- -20 °C
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- Target
- NOTCH2 (Notch 2 (NOTCH2))
- Andere Bezeichnung
- NOTCH2 (NOTCH2 Produkte)
- Synonyme
- AGS2 Protein, HJCYS Protein, hN2 Protein, AI853703 Protein, N2 Protein, notch6 Protein, sb:cb884 Protein, neurogenic locus notch homolog protein 2 Protein, notch 2 Protein, notch 3 Protein, LOC581186 Protein, NOTCH2 Protein, notch3 Protein, Notch2 Protein, notch2 Protein
- Hintergrund
- Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .
- Molekulargewicht
- 80.5 kDa
- Pathways
- Notch Signalweg, Stem Cell Maintenance
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