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Claudin 18.2 protein-VLP

Spezies: Human Wirt: HEK-293 Cells VLP
Produktnummer ABIN7199152
  • Target
    Claudin 18.2
    Protein-Typ
    VLP
    Spezies
    • 6
    • 1
    Human
    Quelle
    • 4
    • 3
    HEK-293 Cells
    Verwendungszweck
    Human Claudin-18.2 Full Length Protein-VLP (HEK293)
    Sequenz
    Met 1 - Val 261
    Produktmerkmale
    Human Claudin-18.2 Full Length Protein-VLP (CL2-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Val 261 (Accession # P56856-2 ).
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Applikationshinweise
    The protein has a calculated MW of 27.7 kDa.
    Kommentare

    Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS, pH 7.4
    Lagerung
    -80 °C
    Informationen zur Lagerung
    -70°C
  • Target
    Claudin 18.2
    Andere Bezeichnung
    Claudin-18.2
    Hintergrund
    Synonyms: Claudin-18.2,CLDN18,Claudin-18,
    Description: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
    Molekulargewicht
    27.7 kDa
    NCBI Accession
    NP_001002026
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