Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CXCR4 Protein-VLP

CXCR4 Spezies: Human Wirt: HEK-293 Cells VLP
Produktnummer ABIN7199192
  • Target Alle CXCR4 Proteine anzeigen
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Protein-Typ
    VLP
    Spezies
    • 10
    • 3
    • 2
    • 1
    Human
    Quelle
    • 8
    • 3
    • 3
    HEK-293 Cells
    Verwendungszweck
    Human CXCR4 / CD184 Full Length Protein-VLP (HEK293)
    Sequenz
    Met 1 - Ser 352
    Produktmerkmale
    Human CXCR4 Full Length Protein-VLP (CX4-H5219) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ser 352 (Accession # P61073-1).
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product CXCR4 Protein
  • Applikationshinweise
    The protein has a calculated MW of 41.6 kDa.
    Kommentare

    Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS, pH 7.4
    Lagerung
    -80 °C
    Informationen zur Lagerung
    -70°C
  • Target
    CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))
    Andere Bezeichnung
    CXCR4 / CD184 (CXCR4 Produkte)
    Hintergrund
    Synonyms: CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM,
    Description: C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells.
    Molekulargewicht
    41.6 kDa
    NCBI Accession
    NP_003458
    Pathways
    Regulation of Cell Size, CXCR4-mediated Signaling Events
Sie sind hier:
Kundenservice