Crystallography grade
KIR2DL4
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, WB, SDS, Crys
Crystallography grade
KIR2DL4
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, WB, SDS, Crys
Crystallography grade
KIR2DL4
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, WB, SDS, Crys
KIR2DL4
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
AbP, STD
Applikationshinweise
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.5 kDa. The protein migrates as 55-60 kDa under reducing (R) condition due to glycosylation.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
Lagerung
-20 °C
Informationen zur Lagerung
-20°C
Target
KIR2DL4/CD158d (KIR2DL4)
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))
G9P Protein, CD158D Protein, KIR103 Protein, KIR103AS Protein, KIR2DL4 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Protein, KIR2DL4 Protein
Hintergrund
Synonyms: CD158d, Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. Soluble HLA-G binds to KIR2DL4 in endosomes and activates the pathway of DNA-PKcs (DNA-dependent protein kinase, catalytic subunit)-AKT-NF-κB signals. The stimulation of the ITIM of KIR2DL4 protein brings about the recruitment and activation of non-receptor protein phosphatases Src homology 2 domain-containing tyrosine phosphatase (SHP)-1 and SHP-2, and the following inhibition of CD16/FcγRIIIa signaling pathway in human NK cells.