IL17C Protein (His-Avi Tag,Biotin)

Produktnummer ABIN7199575

Produktdetails

Target: IL17C (Interleukin 17C (IL17C))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL17C Protein ist gelabelt mit His-Avi Tag,Biotin.

Verwendungszweck: Biotinylated Mouse IL-17C Protein, His,Avitag™ (MALS verified)

Sequenz: Asp 17 - Gln 194

Produktmerkmale: Biotinylated Mouse IL-17C, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Asp 17 - Gln 194 (Accession # Q8K4C5-1).

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Güteklasse: MALS verified

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 23.4 kDa. The protein migrates as 25-27 kDa under reducing (R) condition due to glycosylation.

Kommentare:

Ready-to-use Avitag™ biotinylated protein:
The product is exclusively produced using the Avitag™ technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, 0.5 M Arginine, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: IL17C (Interleukin 17C (IL17C))

Andere Bezeichnung: IL-17C (IL17C Produkte)

Synonyme: IL17C Protein, il17-3 Protein, CX2 Protein, IL-17C Protein, IL-21 Protein, interleukin 17C Protein, interleukin 17c Protein, IL17C Protein, il17c Protein, Il17c Protein

Hintergrund: Synonyms: IL-17C,Cytokine CX2,IL17C,
Interleukin-17C(IL-17C) is a glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity, binds to a heterodimer formed by IL17RA and IL17RE. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes.

Molekulargewicht: 23.4 kDa

NCBI Accession: NP_665833

Pathways: Cellular Response to Molecule of Bacterial Origin