BCL2L1 Protein (His tag)

Produktnummer ABIN7319690

Produktdetails

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses BCL2L1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human BCL2L1/Bcl-XL Protein (His Tag)

Sequenz: Met1-Arg212

Produktmerkmale: Recombinant Human BCL2L1 is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 50 mM KCl, 20 % Glycerol, pH 7.5.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: BCL2L1/Bcl-XL (BCL2L1 Produkte)

Hintergrund:

Background: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

Synonym: Bcl-2-Like Protein 1, Bcl2-L-1, Apoptosis Regulator Bcl-X, Bcl-X,bcl-xL,BCL-XL/S,bcl-xS,BCL2L,BCLX,BCLXL,BCLXS,PPP1R52

Molekulargewicht: 24.85 kDa

UniProt: Q07817

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling