Cadherin 5 Protein (CDH5) (His tag)
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- Target Alle Cadherin 5 (CDH5) Proteine anzeigen
- Cadherin 5 (CDH5)
- Protein-Typ
- Recombinant
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Cadherin 5 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Mouse VE-Cadherin/CDH5 Protein (His Tag)
- Sequenz
- Met 1-Ala 592
- Produktmerkmale
- A DNA sequence encoding the mouse CDH5 (NP_033998.2) extracellular domain (Met 1-Ala 592) was fused with a polyhistidine tag at the C-terminus.
- Reinheit
- > 90 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product CDH5 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Cadherin 5 (CDH5)
- Andere Bezeichnung
- VE-Cadherin/CDH5 (CDH5 Produkte)
- Synonyme
- 7B4 Protein, AA408225 Protein, Cd144 Protein, VE-Cad Protein, VECD Protein, VEcad Protein, Vec Protein, wu:fc88a07 Protein, CD144 Protein, cadherin-5 Protein, cadherin 5 Protein, CDH5 Protein, Cdh5 Protein, cdh5 Protein
- Hintergrund
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Background: Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
Synonym: 7B4,AA408225,Cd144,VE-Cad,Vec,VEcad,VECD
- Molekulargewicht
- 63.5 (or 66) kDa
- NCBI Accession
- NP_033998
- Pathways
- Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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