CTSA Protein (His tag)

Produktnummer ABIN7194664

Produktdetails

Target: CTSA (Cathepsin A (CTSA))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CTSA Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Cathepsin A/CTSA Protein (His Tag)

Sequenz: Met 1-Tyr 480

Produktmerkmale: A DNA sequence encoding the human cathepsin A isoform b (Met 1-Tyr 480) (NP_001121167.1) was expressed with a N-terminal signal peptide and a C-terminal polyhistidine tag.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 25 mM Tris, 0.15 mM NaCl, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CTSA (Cathepsin A (CTSA))

Andere Bezeichnung: Cathepsin A/CTSA (CTSA Produkte)

Synonyme: Ppgb Protein, beta-galactosidase 2 Protein, PPGB Protein, GLB2 Protein, GSL Protein, NGBE Protein, PPCA Protein, AU019505 Protein, cathepsin A Protein, beta-galactosidase 2 Protein, Ctsa Protein, BGAL2 Protein, CTSA Protein

Hintergrund:

Background: Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

Synonym: Lysosomal protective protein,CTSA,Carboxypeptidase C,Carboxypeptidase L,Cathepsin A,GLB2,GSL,NGBE,PPCA,PPGB

Molekulargewicht: 53 kDa

NCBI Accession: NP_001121167