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CD59 Protein (CD59) (His tag)

CD59 Spezies: Ratte Wirt: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Produktnummer ABIN7321145
  • Target Alle CD59 Proteine anzeigen
    CD59
    Protein-Typ
    Recombinant
    Spezies
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Quelle
    • 15
    • 11
    • 5
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD59 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Rat CD59 Protein (His Tag)
    Sequenz
    Met1-Asn100
    Produktmerkmale
    A DNA sequence encoding the rat CD59 (P27274) (Met1-Asn100) was expressed, fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 95 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CD59 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD59
    Andere Bezeichnung
    CD59 (CD59 Produkte)
    Synonyme
    16.3A5 Protein, 1F5 Protein, EJ16 Protein, EJ30 Protein, EL32 Protein, G344 Protein, HRF-20 Protein, HRF20 Protein, MAC-IP Protein, MACIF Protein, MEM43 Protein, MIC11 Protein, MIN1 Protein, MIN2 Protein, MIN3 Protein, MIRL Protein, MSK21 Protein, p18-20 Protein, Cd59a Protein, Cd59b Protein, MACIP Protein, CD59 molecule (CD59 blood group) Protein, CD59 molecule Protein, CD59 Protein, Cd59 Protein
    Hintergrund

    Background: CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

    Synonym: CD59

    Molekulargewicht
    10.3 kDa
    UniProt
    P27274
    Pathways
    Komplementsystem
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